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Distribution of basement membrane type IV collagen alpha chains in ameloblastoma: an immunofluorescence study

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Distribution of basement membrane type IV collagen alpha chains in ameloblastoma: an immunofluorescence study

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Article Abstract:

Background: Type IV collagen, a heterotrimeric molecule that exists in six genetically distinct forms, alpha1(IV)-alpha6(IV) is a major structural component of basement membrane (BM) and acts as a scaffold for other BM constituents. Methods: Indirect immunofluorescence using alpha chain-specific monoclonal antibodies was employed to clarify basement membrane (BM) collagen IV distribution in two ameloblastoma, and for comparison, on oral mucosa and tooth germ. Results: Ameloblastoma BM expressed five of six genetically distinct forms of collagen IV: alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) chains occurred as intense linear stainings without disruption around neoplastic epithelium, and this expression pattern was fundamentally similar to oral mucosa BM; alpha4(IV) expression was rare and occurred around nests of primitive tumor cells or potentially invasive sites. The tooth germ demonstrated a stage- and position-specific collagen IV distribution: the inner enamel epithelium BM expressed alpha1(IV), alpha2(IV), and alpha4(IV) except in the cuspal predentine region; and the outer enamel epithelium BM expressed alpha1(V), alpha2(IV), alpha5(IV), and alpha6(IV) chains. Conclusions: Results suggest that collagen IV alpha chain distribution in ameloblastoma BM plays an important role in tumor cytodifferentiation and progression.

Author  Nakano, K.

 Siar, C. H.

 Nagai, N.

 Naito, I.

 Sado, Y.

 Nagatsuka, H.

 Hoh, C.

 Kurada, K.

 Tsujigiwa, H.

 Gunduz, M.

Source Journal of Oral Pathology & Medicine

ISSN 0904-2512

DOI 10.1034/j.1600-0714.2002.00162.x Volume (Issue) 31(8)

Page 494-499

Year 2002

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Keyword:

Ameloblastoma,collagen IV profile,indirect immunofluorescence,defined monoclonal- antibodies,human fetal teeth,odontogenic-tumors,immunohistochemical demonstration basal lamina,expression,proteins,benign,tooth

Please Cite As:

NAKANO, K., SIAR, C. H., NAGAI, N., NAITO, I., SADO, Y., NAGATSUKA, H., HOH, C., KURADA, K., TSUJIGIWA, H. & GUNDUZ, M. 2002. Distribution of

basement membrane type IV collagen alpha chains in ameloblastoma: an immunofluorescence study. Journal of Oral Pathology & Medicine, 31, 494- 499.

URL:

 http://apps.webofknowledge.com search via Accession No >>000178047900009

 http://www.ncbi.nlm.nih.gov/pubmed/12220358

 http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0714.2002.00162.x/abstract

http://apps.webofknowledge.com http://www.ncbi.nlm.nih.gov/pubmed/12220358 http://onlinelibrary.wiley.com/doi/10.1034/j.1600-0714.2002.00162.x/abstract

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